Substance Abuse – Lysergic acid diethylamide (LSD)
Anesthesia Implications
Anesthesia Implications
Succinylcholine – Effects of succinylcholine can be prolonged due to anticholinesterases inhibition.
Detection window – 36–96 h
False positives – Amitriptyline, sumatriptan
Substance abuse (general considerations) – If necessary, get your urine/blood screen early. The urine screen will take 30 minutes and a serum screen will be closer to an hour. Almost all drug screens will return results for marijuana, amphetamines/methamphetamines, phencyclidine (PCP), cocaine, opioids, barbiturates, and benzodiazepines. Generally speaking, if the patient is acutely intoxicated, the case should be cancelled/delayed. Refer to your facility to get policies on cancellations/delays.
Pathophysiology
Other names – Acid A, Strawberry, and Microdots
Symptoms – Low doses increase light and sound sensitivity. High doses cause visual and emotional disturbances. General symptoms may also include mydriasis, increased wakefulness, and reduced appetite
Mechanism – unknown. LSD has anticholinesterase properties. Inhibits monoamine oxidase (MAO), which potentiates endogenous seratonin and histamine effects.
Toxicity symptoms – can include hallucinations, frothing, dilated pupils, synesthesia, tachycardia, tachypnea, hyperthermia/hypothermia, hypertonia, and hyperglycemia.
Drug duration – last from 6 to 10 hours